Formaldehyde → N-hydroxymethyl-4-chloro-3-methylpyrazole
Reaction equation
[Cl:1][C:2]1[C:3]([CH3:7])=[N:4][NH:5][CH:6]=1.[CH2:8]=[O:9]>CO>[OH:9][CH2:8][N:5]1[CH:6]=[C:2]([Cl:1])[C:3]([CH3:7])=[N:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
116 g (1.0 mol) of 4-chloro-3-methylpyrazole in 50 ml of methanol were dissolved in 100 g (1.0 mol) of formalin solution (30%) at room temperature. Water and methanol were then evaporated. The title compound remained as a white solid (yield 95%).
Workup
- customWater and methanol were then evaporated
Sources & evidence
- ORD record
- ord-dfd5ee8d4f8142afabf7ec74d7a7bb2d
- Source dataset
- uspto-grants-2002_12
- Patent number
- US06488734B1
Reaction notes
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