2,3-Epoxyhexanol → HCID 18381125, compound

HRID 2297344

Reaction equation

HRID 2297344 reaction equation
[F:1][C:2]1[C:3]([OH:26])=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[CH2:8][CH:7]([C:13]1[N:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:15][N:14]=1)[CH2:6][CH2:5]2.[CH2:27]([CH:30]1[O:32][CH:31]1[CH2:33]O)[CH2:28][CH3:29]>>[F:1][C:2]1[C:3]([O:26][CH2:33][CH:31]2[CH:30]([CH2:27][CH2:28][CH3:29])[O:32]2)=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[CH2:8][CH:7]([C:13]1[N:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:17][N:18]=1)[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 5435652,3-EpoxyhexanolHCID 183811186,7-Difluoro-2-(5-hexyloxypyrimidin-2-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 18381125HCID 18381125, compound

Procedure

From 6,7-difluoro-2-(5-hexyloxypyrimidin-2-yl)-5-hydroxy-1,2,3,4-tetrahydronaphthalene and (3-propyloxiranyl)methanol by means of the Mitsunobu reaction.

Sources & evidence

ORD record
ord-9cd23af99b484c7aabedfe8ad398ba58
Source dataset
uspto-grants-2002_12
Patent number
US06491989B1

Linked notes

Loading…