Leucinamide hydrochloride → N-[N-(3,4-dichlorophenyl)-L-alanyl]-L-leucine amide

HRID 2299545

Reaction equation

HRID 2299545 reaction equation
Cl.[NH2:2][C@H:3]([C:8]([NH2:10])=[O:9])[CH2:4][CH:5]([CH3:7])[CH3:6].[Cl:11][C:12]1[CH:13]=[C:14]([NH:19][CH:20]([C:22](O)=[O:23])[CH3:21])[CH:15]=[CH:16][C:17]=1[Cl:18]>>[Cl:11][C:12]1[CH:13]=[C:14]([NH:19][C@H:20]([C:22]([NH:10][C:8](=[O:9])[C@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[NH2:2])=[O:23])[CH3:21])[CH:15]=[CH:16][C:17]=1[Cl:18]

Participants

3

Reactant 2

HCID 2733199Leucinamide hydrochlorideHCID 69164262-(3,4-Dichloro-phenylamino)-propionic Acid

Product 1

HCID 131721930N-[N-(3,4-dichlorophenyl)-L-alanyl]-L-leucine amide

Procedure

Following General Procedure D and using L-leucinamide hydrochloride (Sigma) and N-(3,4-dichlorophenyl)-D,L-alanine (from Example A above), the title compound was prepared. This compound was then purified by column chromatography, eluted first with 1:1 EtOAc/hexane, then with 5% MeOH in methylene chloride.

Workup

  1. customThis compound was then purified by column chromatography
  2. washeluted first with 1:1 EtOAc/hexane

Sources & evidence

ORD record
ord-668fd6c6dc1c48f9a0e4a10c089d4849
Source dataset
uspto-grants-2002_12
Patent number
US06495693B2

Linked notes

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