1,4-Dioxane hydrochloride → 1-(5-Bromo-1,3-thiazol-2-yl)methanamine hydrochloride
Reaction equation
O1CCOCC1.[ClH:7].[Br:8][C:9]1[S:13][C:12]([CH2:14][NH:15]C(OC(C)(C)C)=O)=[N:11][CH:10]=1>C(O)C>[ClH:7].[NH2:15][CH2:14][C:12]1[S:13][C:9]([Br:8])=[CH:10][N:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4 N hydrochloric acid dioxane solution (2.3 L) was added dropwise to a solution (1.6 L) of 542 g of 5-bromo-2-t-butoxycarbonylaminomethylthiazole in ethanol at an internal temperature of 40° C. over a period of 1.1 hr. The mixture was stirred until the internal temperature reached 23° C. The precipitated crystal was collected by filtration, was washed twice with ethanol, and was then dried under the reduced pressure to give 394 g of 2-aminomethyl-5-bromothiazole hydrochloride.
Workup
- customreached 23° C
- filtrationThe precipitated crystal was collected by filtration
- washwas washed twice with ethanol
- customwas then dried under the reduced pressure
Sources & evidence
- ORD record
- ord-f192648d27424bdeb68709419849ba84
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07563901B2
Reaction notes
Loading…