Ethyl 4-amino-1-piperidinecarboxylate → 1-(Ethoxycarbonyl)-4-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methylamino]piperidine

HRID 2300346

Reaction equation

HRID 2300346 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:4][CH2:3]1.Cl[CH2:14][C:15]1[CH:20]=[CH:19][N:18]=[C:17]([C:21]2[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=2)[CH:16]=1>>[CH2:11]([O:10][C:8]([N:5]1[CH2:4][CH2:3][CH:2]([NH:1][CH2:14][C:15]2[CH:20]=[CH:19][N:18]=[C:17]([C:21]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=3)[CH:16]=2)[CH2:7][CH2:6]1)=[O:9])[CH3:12]

Participants

3

Reactant 2

HCID 100867Ethyl 4-amino-1-piperidinecarboxylateHCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine

Product 1

HCID 225580261-(Ethoxycarbonyl)-4-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methylamino]piperidine

Procedure

4-Amino-1-(ethoxycarbonyl)piperidine (341 mg) and 4-chloromethyl-2-( 3,4,5-trimethoxyphenyl)pyridine (300 mg) were condensed in the same manner as described in Example 2 to give the title compound.

Workup

  1. customcondensed in the same manner

Sources & evidence

ORD record
ord-fd24eacda3d4400ebbed838368c9894d
Source dataset
uspto-grants-2002_12
Patent number
US06498169B1

Linked notes

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