Aniline → HCID 22557918, compound
Reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[CH:15]=[C:14]([CH2:16][N:17]3[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]3)[CH:13]=[CH:12][N:11]=2)=[CH:4][C:3]=1[O:24][CH3:25].[NH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[NH:26]([CH:20]1[CH2:21][CH2:22][N:17]([CH2:16][C:14]2[CH:13]=[CH:12][N:11]=[C:10]([C:5]3[CH:4]=[C:3]([O:24][CH3:25])[C:2]([Cl:1])=[C:7]([O:8][CH3:9])[CH:6]=3)[CH:15]=2)[CH2:18][CH2:19]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1Participants
3
Procedure
1-[[2-(4-Chloro-3,5-dimethoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (600 mg) and aniline (0.18 mL) were reacted in the same manner as described in Preparation Example 37 to give the title compound.
Workup
- customas described in Preparation Example 37
Sources & evidence
- ORD record
- ord-e618fa39c657429b8216f5d349ac33be
- Source dataset
- uspto-grants-2002_12