L-Alanine → (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

HRID 23008

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10](Cl)=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:13][C@H:14]([C:16]([OH:18])=[O:17])[CH3:15]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:13][C@H:14]([C:16]([OH:18])=[O:17])[CH3:15])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

Reactant 2

HCID 5950L-Alanine

HCID 27827232-(3,5-Difluorophenyl)acetyl chloride

Product 1

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

Procedure

Using General Procedure II-C, the title compound was prepared from 3,5-difluorophenylacetyl chloride (General Procedure II-B) and L-alanine (Aldrich).

Sources & evidence

ORD record: ord-6a49e539fc5943aaadc244e455ff551c
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06849650B2

Linked notes

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