3,5-Difluorophenylacetic acid → HCID 10391797, compound

HRID 23015

Reaction equation

HRID 23015 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:13][CH:14]([C:16]1[N:17]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH2:18][C:19]([C:28]([O:30][CH3:31])=[O:29])([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:20]=1)[CH3:15]>>[C:35]([O:34][C:32]([N:17]1[CH2:18][C:19]([C:28]([O:30][CH3:31])=[O:29])([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:20]=[C:16]1[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH3:15])=[O:33])([CH3:37])([CH3:36])[CH3:38]

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 225924612-(1-Aminoethyl)-1-tert-butoxycarbonyl-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline

Product 1

HCID 10391797HCID 10391797, compound

Procedure

Following General Procedure C above and using 3,5-difluorophenylacetic acid (Aldrich) and 1-tert-butoxycarbonyl-2-(1-aminoethyl)-4-methoxycarbonyl-4-phenylmethyl-2-imidazoline (Example J), the title compound was prepared as an amorphous solid. The reaction was monitored by tlc (Rf=0.34 in 2:1 hexanes/EtOAc) and the product was purified by flash column chromatography.

Workup

  1. customthe product was purified by flash column chromatography

Sources & evidence

ORD record
ord-5ab1731a61c04d56b1d251826165876c
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Linked notes

Loading…