Bromhydrol → HCID 11511649, compound
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])=[O:10])=[C:4]([OH:20])[C:3]=1[S:21]([N:24]([CH2:29][CH2:30][O:31]C)[CH2:25][CH2:26][O:27]C)(=[O:23])=[O:22].[Br-].[Al+3].[Br-].[Br-]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=2[Cl:19])=[O:10])=[C:4]([OH:20])[C:3]=1[S:21]([N:24]([CH2:29][CH2:30][OH:31])[CH2:25][CH2:26][OH:27])(=[O:23])=[O:22]Participants
3
Procedure
Following the deprotection procedure outlined in example 58, N-[4-chloro-3-[N″,N″-di-(2-methoxyethyl)aminosulfonyl]-2-hydroxyphenyl]-N′(2,3-dichlorophenyl) urea (15 mg, 0.028 mmol) and aluminum bromide (18.7 mg, 0.07 mmol) were reacted to give the desired product (2 mg, 14%). LC-MS 500.0 (M+).
Workup
- customwere reacted
Sources & evidence
- ORD record
- ord-2509ecaf4a714c1bb48908d561bfd18c