3,5-Difluorophenylacetic acid → HCID 178496843, compound

HRID 23017

Reaction equation

HRID 23017 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:13][CH:14]([C:16]1[N:17](C(OC(C)(C)C)=O)[CH2:18][C:19]([C:27]([O:29][CH3:30])=[O:28])([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:20]=1)[CH3:15]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:13][CH:14]([C:16]2[NH:17][CH2:18][C:19]([C:27]([O:29][CH3:30])=[O:28])([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:20]=2)[CH3:15])=[O:12])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 22592446HCID 22592446, compound

Product 1

HCID 178496843HCID 178496843, compound

Procedure

Following General Procedure C above and using 3,5-difluorophenylacetic acid (Aldrich) and 1-tert-butoxycarbonyl-2-(1-aminoethyl)-4-methoxycarbonyl-4-phenyl-2-imidazoline (Example K), the title compound was prepared as a white foam (90%). The reaction was monitored by tlc (Rf=0.39 in 3:2 hexanes/EtOAc) and the product was purified by flash column chromatography.

Workup

  1. customthe product was purified by flash column chromatography

Sources & evidence

ORD record
ord-9c6f40ad374f4524be641c8c618468b0
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Linked notes

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