Thionyl Chloride → Quinoline-6-carbonyl chloride hydrochloride

Reaction equation

[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>>[ClH:16].[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([Cl:16])=[O:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 825716-Quinolinecarboxylic acid

Product 1

HCID 22136358Quinoline-6-carbonyl chloride hydrochloride

Procedure

6-Quinolinecarboxylic acid was refluxed in thionyl chloride for 30 min. The excess thionyl chloride was then removed by rotary evaporation (90° C.) to provide 6-quinolinecarbonyl chloride hydrochloride.

Workup

customThe excess thionyl chloride was then removed by rotary evaporation (90° C.)

Sources & evidence

ORD record: ord-4ec76eb7ff014f93be1aece7c341a9fd
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06429207B1

Reaction notes

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