2-Thiopheneglyoxylic acid → 2(1H)-Quinoxalinone
Reaction equation
CO[C:3]1[CH:4]=[C:5]([NH2:12])[C:6]([NH2:11])=[CH:7][C:8]=1OC.S1C=CC=C1[C:18](=O)[C:19](O)=[O:20]>>[NH:12]1[C:5]2[C:6](=[CH:7][CH:8]=[CH:3][CH:4]=2)[N:11]=[CH:18][C:19]1=[O:20]Participants
3
Procedure
The quinoxalin-2-one of the present example is prepared with 4,5-Dimethoxy-benzene-1,2-diamine and (thiophen-2-yl) oxo-acetic acid via the method described in Example 12 to afford 6,7-Methoxy-3-thiophen-2-yl-1H-quinoxalin-2-one.
Sources & evidence
- ORD record
- ord-8d3ee40393d043789041c6df9f96f1e7
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07566719B2
Reaction notes
Loading…