Benzylamine → 2-(Isoxazol-5-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine

Reaction equation

[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[C:11]2[C:23]([CH3:24])=[CH:22][S:21][C:12]=2[N:13]=[C:14]([C:16]2[O:20][N:19]=[CH:18][CH:17]=2)[N:15]=1>>[O:20]1[C:16]([C:14]2[N:15]=[C:10]([NH:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:11]3[C:23]([CH3:24])=[CH:22][S:21][C:12]=3[N:13]=2)=[CH:17][CH:18]=[N:19]1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 184601204-Chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184601632-(Isoxazol-5-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of benzylamine with 4-chloro-2-(isoxazol-5-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-46f875ce77c54a8ea29f3663e19c2cd2
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06432950B1

Reaction notes

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