Cyclopropanecarbonitrile → Cyclopropyl 2-amino-3,5-dimethylphenyl ketone

HRID 2303728Notes

Reaction equation

[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[C:10](=[O:12])[CH3:11].[CH:13]1(C#N)C[CH2:14]1>>[NH2:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([CH3:9])=[CH:4][C:3]=1[C:10]([CH:11]1[CH2:14][CH2:13]1)=[O:12]

Participants

Reactant 2

HCID 79637Cyclopropanecarbonitrile

HCID 105831361-(2-Amino-3,5-dimethylphenyl)ethan-1-one

Product 1

HCID 23445385Cyclopropyl 2-amino-3,5-dimethylphenyl ketone

Procedure

Cyclopropyl 2-amino-3,5-dimethylphenyl ketone was synthesized in the same fashion as for 2′-amino-3′,5′-dimethylacetophenone (Example 39) except that cyclopropyl cyanide was used instead of acetonitrile.

Sources & evidence

ORD record: ord-6c9f3208cd54402493b06ae0767cd059
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06432994B1

Reaction notes

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