HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutanol → N-(3,5-difluorophenyl)alanine Iso-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutanol | HCID 6560 | — |
| Reactant | N-(3,5-difluorophenyl)alanine | HCID 53936901 | — |
| Product | N-(3,5-difluorophenyl)alanine Iso-butyl Ester | HCID 54289378 | — |
Reaction Steps
Following General Procedure AH above and using N-(3,5-difluorophenyl)alanine (from Example AC above) and iso-butanol, the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.9 in 3% methanol/methylene chloride) and purification was by preparative plate chromatography (silica gel using 3% methanol/methylene chloride as the eluant).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849650B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-d5613df61c1a406e8d4bc734c58fdd6b |
| Source note | uspto-grants-2005_02 |