1,3-Diamino-2-propanol → (RS)-1-Amino-3-[[2-(4-chlorophenyl)-4-quinolinyl]amino]-2-propanol dihydrochloride

Reaction equation

[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:3]=1.[NH2:19][CH2:20][CH:21]([OH:24])[CH2:22][NH2:23]>>[ClH:1].[ClH:1].[NH2:19][CH2:20][CH:21]([OH:24])[CH2:22][NH:23][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH:3]=1

Participants

Reactant 2

HCID 611571,3-Diamino-2-propanol

HCID 112195464-Chloro-2-(4-chlorophenyl)quinoline

Product 1

HCID 18433049(RS)-1-Amino-3-[[2-(4-chlorophenyl)-4-quinolinyl]amino]-2-propanol dihydrochloride

Procedure

The title compound, m.p. 283-287° C., and MS: m/e=328.2 (M+H+), was prepared from 4-chloro-2-(4-chloro-phenyl)-quinoline and 1,3-diamino-2-propanol.

Sources & evidence

ORD record: ord-7cb60a660f5449f69343a7e745b02eae
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06440995B1

Reaction notes

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