Methanol → HCID 18433366, compound
Reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].S(=O)(=O)(O)O.[CH3:20]O>O>[OH:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([O:14][CH3:20])=[O:13])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
3-hydroxy-4nitrophenylacetic acid (1.1 g) was refluxed in methanol (20 ml) containing 0.5 ml of conc. sulphuric acid for 4 hrs., diluted with water and extracted with diethyl ether. The organic layer was separated, washed with aqueous sodium bicarbonate, brine, dried and then evaporated to dryness to give methyl 3-hydroxy-4-nitrophenylacetate (1.2 g) as a gum which crystallised on standing.
Workup
- extractionextracted with diethyl ether
- customThe organic layer was separated
- washwashed with aqueous sodium bicarbonate, brine
- customdried
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-0198d455d3b0424286f0615f845cd24a
- Source dataset
- uspto-grants-2002_08
- Patent number
- US06441012B1
Reaction notes
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