Methanol → HCID 18433362, compound
Reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:18]([CH3:22])[C:19]([OH:21])=[O:20])[CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:28]O>>[CH3:28][O:20][C:19](=[O:21])[CH:18]([C:11]1[CH:12]=[CH:13][C:14]([N+:15]([O-:17])=[O:16])=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1)[CH3:22]Participants
4
Procedure
A mixture of 2-(3-benzyloxy4-nitrophenyl)propionic acid(1.89 g), methanol(30 mL) and concentrated sulphuric acid(1 mL) was heated at reflux for 3 h, cooled to ambient temperature and the mixture was extracted with ether. The extract washed with brine, dried and evaporated to dryness to give methyl-2-(3-benzyloxy-4-nitrophenyl)propionate(1.8 g). [m/e316(MH+)].
Workup
- temperaturewas heated
- temperatureat reflux for 3 h
- extraction