HCID 18433359, compound → Benzoxazole

Reaction equation

COC(=O)CCCOC1C=C(N)C=CC=1.COC(=O)C([C:25]1[CH:30]=[CH:29][C:28]([N+:31]([O-])=O)=[C:27]([O:34][CH2:35]C2C=CC=CC=2)[CH:26]=1)(C)C(OC)=O>>[O:34]1[C:27]2[CH:26]=[CH:25][CH:30]=[CH:29][C:28]=2[N:31]=[CH:35]1

Participants

Reactant 2

HCID 18433359HCID 18433359, compound

HCID 18433369HCID 18433369, compound

Product 1

HCID 9228Benzoxazole

Procedure

Methyl-4-(5-aminophenoxy)butyrate was made as described in example 7 above and coupled with dimethyl-2-(3-benzyloxy-4-nitrophenyl)-2-methylmalonate according to the method described in example 7 to produce the methyl ester of 2-Anilino-6-(2-(3-[3-carboxypropoxy]anilino carbonyl)prop-2-yl))benzoxazole.

Sources & evidence

ORD record: ord-cd2c37a35b3c4b028ec357b39b8b77ea
Source dataset: uspto-grants-2002_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06441012B1

Reaction notes

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