N,N-Dimethylglycine → 1-[4-(4-morpholinylcarbonyl)phenyl]-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Temperature

130 °C

A mixture of 4-[(4-iodophenyl)carbonyl]morpholine (1.90 g, 6.0 mmol), 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole (1.14 g, 6.0 mmol), copper (I) oxide (10 mol %, 0.6 mmol, 86 mg), N,N-dimethylglycine (20 mol %, 1.2 mmol, 124 mg), and cesium carbonate (12.0 mmol, 3.91 g) in dimethylsulfoxide (16 ml) was stirred in an oilbath heated at 130° C. for 24 h under argon and then allowed to cool to room temperature. The reaction mixture was partitioned between dichloromethane (30 ml) and water (30 ml). The organic layer was separated and dried over sodium sulphate. The solvent was removed by rotary evaporation to give a dark brown residue that was added to a 20 g isolute pre-packed silica column and eluted from 0-50% ethyl acetate in petroleum ether to give the title compound as a brown gum (1.86 g, 82%).

1. temperatureto cool to room temperature
2. customThe reaction mixture was partitioned between dichloromethane (30 ml) and water (30 ml)
3. customThe organic layer was separated
4. dry with materialdried over sodium sulphate
5. customThe solvent was removed by rotary evaporation
6. customto give a dark brown residue that
7. additionwas added to a 20 g isolute pre-packed silica column
8. washeluted from 0-50% ethyl acetate in petroleum ether

ORD record

ord-6ad4561296a5482eb86433f37de142e2

Source dataset

uspto-grants-2009_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07566735B2