Methylhydrazine → HCID 3953327, compound
Reaction equation
[CH:1]([C:3]([C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1)=[CH:4]O)=O.[CH3:15][NH:16][NH2:17]>C(O)C>[CH3:15][N:16]1[CH:4]=[C:3]([C:6]2[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=2)[CH:1]=[N:17]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of 6-(1-formyl-2-hydroxyvinyl)pyridine-3-carboxylic acid (1.93 g) Eastman Chemicals) in absolute ethanol (50 ml) and methylhydrazine (0.50 g) was stirred for 18 hours at room temperature. The reaction mixture was filtered to give the product (1.30 g). The filtrate was evaporated to give a solid which was recrystallized from ethyl acetate to give an analytical sample of the title compound (0.55 g), m.p. 262-264° C.
Workup
- filtrationThe reaction mixture was filtered
Sources & evidence
- ORD record
- ord-65112631dd2045e2b8b6f59a5b20d5d0
- Source dataset
- uspto-grants-2004_12
- Patent number
- US06831079B1
Reaction notes
Loading…