1-(4-Bromo-2-thienyl)-1-propanol → 4-Bromo-2-propionylthiophene

HRID 2307572

Reaction equation

HRID 2307572 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]([OH:10])[CH2:8][CH3:9])[S:5][CH:6]=1>ClCCl.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[CH:3]=[C:4]([C:7](=[O:10])[CH2:8][CH3:9])[S:5][CH:6]=1

Participants

4

Reactant 1

HCID 226069011-(4-Bromo-2-thienyl)-1-propanol

Product 1

HCID 8189324-Bromo-2-propionylthiophene

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

11.5 g (52 mmol) of 1-(4-bromo-2-thiophenyl)-1-propanol are dissolved in 300 mL of dichloromethane. 60 g (690 mmol) of manganese dioxide are added and the reaction medium is stirred for 14 hours and then filtered. The desired product is obtained in the form of an orange-coloured oil (m=11.4 g; Y=99%).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-63d3a1ebd9e74ddabe581e351eae2e72
Source dataset
uspto-grants-2004_12
Patent number
US06831106B1

Linked notes

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