2-Naphthaleneacetic acid → 2-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

HRID 23083

Reaction equation

HRID 23083 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][CH:16]([CH2:24][CH3:25])[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH2:24][CH3:25])[CH:21]([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 113932-Naphthaleneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 536358212-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 2-naphthylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tic on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customtic on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-3883f0db929a4993b915a7575b05ae6c
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Linked notes

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