4,6-Difluoro-1,3-benzothiazol-2-amine → 5-Methyl-thiophene-2-carboxylic acid (4,6-difluoro-benzothiazol-2-yl)-amide

HRID 2308429

Reaction equation

HRID 2308429 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:5]=2[N:6]=1.[CH3:13][C:14]1[S:18][C:17]([C:19](Cl)=[O:20])=[CH:16][CH:15]=1>>[F:12][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:19]([C:17]3[S:18][C:14]([CH3:13])=[CH:15][CH:16]=3)=[O:20])[S:3][C:4]=2[CH:10]=[C:9]([F:11])[CH:8]=1

Participants

3

Reactant 2

HCID 7374064,6-Difluoro-1,3-benzothiazol-2-amineHCID 27600835-Methylthiophene-2-carbonyl chloride

Product 1

HCID 865848975-Methyl-thiophene-2-carboxylic acid (4,6-difluoro-benzothiazol-2-yl)-amide

Procedure

Using 2-amino-4,6-difluoro-benzothiazole and 5-methyl-thiophene-carboxylicacid chloride the title compound was prepared as a yellow solid (74% yield), MS: m/e=310 (M+).

Sources & evidence

ORD record
ord-3076a00d4a0344dab51fa341fc2716fa
Source dataset
uspto-grants-2004_12
Patent number
US06835732B2

Linked notes

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