3-Chlorophenylacetic acid → 2-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

HRID 23086

Reaction equation

HRID 23086 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 155476412-[(3-Chlorophenyl)acetamido)butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 3-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-85d1fe004b3d4ba788f2c94f66c6236e
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Linked notes

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