Acetyl chloride → 2-(N-Acetyl-piperazino)-8-benzylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine

HRID 2308621Notes

Reaction equation

HRID 2308621 reaction equation
[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:31](Cl)(=[O:33])[CH3:32]>CC(C)=O>[C:31]([N:28]1[CH2:27][CH2:26][N:25]([C:16]2[N:17]=[C:18]([N:19]3[CH2:20][CH2:21][O:22][CH2:23][CH2:24]3)[C:13]3[N:12]=[CH:11][N:10]=[C:9]([S:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:14]=3[N:15]=2)[CH2:30][CH2:29]1)(=[O:33])[CH3:32]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 132466RX-RA 69

Product 1

HCID 201501312-(N-Acetyl-piperazino)-8-benzylthio-4-morpholino-pyrimido-[5,4-d]-pyrimidine

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A suspension of 2.1 gm (0.005 mol) of 8-benzylthio-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine (m.p.: 191°-193° C.) in 150 ml of acetone was refluxed for 30 minutes after addition of 0.8 gm (0.01 mol) of acetyl chloride. The solvent was then evaporated in vacuo, and the residue was taken up in approximately 200 ml of water. The reaction product was suction-filtered off, washed with water and dried.

Workup

  1. temperaturewas refluxed for 30 minutes
  2. customThe solvent was then evaporated in vacuo
  3. filtrationThe reaction product was suction-filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-45032f6a60624f5597955547cb199d30
Source dataset
uspto-grants-1987_09
Patent number
US04690923

Reaction notes

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