o-Tolylacetic acid → 2-[(2-methylphenyl)acetamido]butyric Acid Iso-butyl Ester

HRID 23088

Reaction equation

HRID 23088 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 69519o-Tolylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 545734982-[(2-methylphenyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 2-methylphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-6068cc2ea74a43dcb1da6b75e226ef33
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Linked notes

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