o-Fluorobenzaldehyde → 2-(2-Fluorophenyl)-6-methylpyridine

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[C:12]([CH3:14])[CH:11]=[CH:10][CH:9]=1.[F:15]C1C=CC=CC=1C=O>>[F:15][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:13]=[C:12]([CH3:14])[CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 67970o-Fluorobenzaldehyde

HCID 12380163HCID 12380163, compound

Product 1

HCID 212757582-(2-Fluorophenyl)-6-methylpyridine

Procedure

6-(2-fluorophenyl)-2-methylpyridine was prepared substantially according to the procedures of Example 1 for preparing 6-(2-chlorophenyl)-2-methylpyridine except 2-fluorobenzaldehyde was used to afford 6-(2-fluorophenyl)-2-methylpyridine.

Workup

custom6-(2-fluorophenyl)-2-methylpyridine was prepared substantially

Sources & evidence

ORD record: ord-4f22572be696439da9f8188ea9ef9718
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04696938

Reaction notes

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