Ethanol → Ethyl 3-methoxy-4-(7H-purin-8-yl)benzoate
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](N)=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1.[CH2:21]([OH:23])[CH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([O:23][CH2:21][CH3:22])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1Participants
3
Procedure
A quantity of 0.42 gm of 8-(2'-methoxy-4'-chlorocarbonyl-phenyl)-purine hydrochloride (see Example 43) was refluxed in 30 ml of ethanol for 45 minutes. The solvent was evaporated off, and the residue was purified over a silica gel column [eluant:methylene chloride/ethanol (50:1 to 19:1)].
Workup
- customThe solvent was evaporated off
- customthe residue was purified over a silica gel column [eluant:methylene chloride/ethanol (50:1 to 19:1)]
Sources & evidence
- ORD record
- ord-521ed348f7fd4b9b9dd5bdd736d478ae