Ibuprofen, (+-)- → Ibuprofen codeine
Reaction equation
[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.[OH:23][C:24]([CH:26]([C:28]1[CH:37]=[CH:36][C:31]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:25]>>[OH:25][C:24]([CH:26]([C:28]1[CH:29]=[CH:30][C:31]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:36][CH:37]=1)[CH3:27])=[O:23].[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1Participants
3
Reactant 2
Product 1
Procedure
Codeine Phosphate, microcrystalline cellulose (Avicel PH102) and Starch 1500 were dry mixed. An aqueous solution of polyvinylpyrrolidone was then added to the dry powder and the mixture was granulated to give codeine granules. Microcrystalline cellulose (Avicel PH101) was then mixed with the granules. Finally, the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bilayer tablet with a crushing strength of 11-12 kp.
Sources & evidence
- ORD record
- ord-59bd06f1bc794c6582feaf1dc95b8d04
- Source dataset
- uspto-grants-1989_07