1,2,3,4-Tetrahydroquinoline → 2-(1,2,3,4-Tetrahydroquinolin-1-yl)ethan-1-ol

Reaction equation

[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:11](NC(C)CCl)(=[O:13])[CH3:12]>>[OH:13][CH2:11][CH2:12][N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 694601,2,3,4-Tetrahydroquinoline

HCID 20034385N-(1-chloropropan-2-yl)acetamide

Product 1

HCID 101037092-(1,2,3,4-Tetrahydroquinolin-1-yl)ethan-1-ol

Procedure

N-(2-Acetamidopropyl)-1,2,3,4-tetrahydroquinoline was obtained in an analogous way by reacting 1,2,3,4-tetrahydroquinoline with 2-acetamidopropyl chloride.

Sources & evidence

ORD record: ord-9ba3cd5dbb514ea895890d6c1257be1b
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04845030

Reaction notes

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