Toluene → (2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-thiazolo[5,4-b]pyridin-5-yl)(cyclobutyl)methanone

HRID 2310959Notes

Reaction equation

HRID 2310959 reaction equation
[CH3:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[CH:27]1([C:31](=[O:32])[Cl:33])[CH2:28][CH2:29][CH2:30]1.[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:26])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([Sn:22]([CH3:23])([CH3:24])[CH3:25])[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:3][CH2:4][CH2:5][CH2:6]1>>[O:1]1[CH:2]([c:7]2[cH:8][c:9]([F:26])[c:10](-[c:13]3[s:14][c:15]4[n:16][c:17]([C:31]([CH:27]5[CH2:28][CH2:29][CH2:30]5)=[O:32])[cH:18][cH:19][c:20]4[n:21]3)[cH:11][cH:12]2)[O:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 1140TolueneHCID 78705Cyclobutanecarbonyl chlorideHCID 591748322-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-5-(trimethylstannyl)thiazolo[5,4-b]pyridine

Product 1

HCID 67112767(2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-thiazolo[5,4-b]pyridin-5-yl)(cyclobutyl)methanone

Sources & evidence

ORD record
ord-da13a97fe5314ed1a3d496f10a284072
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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