4-Aminohydratropic acid → 2-(Thiophen-3-yl)propanoic acid

HRID 231358

Reaction equation

NC1C=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.CCOC([S-])=[S:17].[K+]>>[S:17]1[CH:6]=[C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:4]=[CH:3]1

Participants

Reactant 2

HCID 430264-Aminohydratropic acid

HCID 2735045Potassium ethylxanthate

Product 1

HCID 131348672-(Thiophen-3-yl)propanoic acid

Procedure

diazotation of 2-(4-aminophenyl)propionic acid and subsequent reaction of diazonium salt with potassium xanthogenate to give 2-(4-thiophenyl)-propionic acid;

Sources & evidence

ORD record: ord-7e271228f81a4b2691c8a55bec5fc011
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04845281

Linked notes

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