Pyridine → N-[5-(3-Fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]propanamide

Reaction equation

[C:27]([CH2:28][CH3:29])(=[O:30])[Cl:31].[Cl:32][CH2:33][Cl:34].[F:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][cH:10][c:11]([NH2:20])[n:12][c:13]1-[c:14]1[cH:15][n:16][cH:17][cH:18][cH:19]1.[cH:21]1[cH:22][cH:23][n:24][cH:25][cH:26]1>>[F:1][c:2]1[cH:3][n:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][cH:10][c:11]([NH:20][C:27]([CH2:28][CH3:29])=[O:30])[n:12][c:13]1-[c:14]1[cH:15][n:16][cH:17][cH:18][cH:19]1

Participants

Reactant 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 62324Propionyl chloride

HCID 160708355-(3-Fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-amine

Product 1

HCID 16071070N-[5-(3-Fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]propanamide

Sources & evidence

ORD record: ord-93753ee66bea45fca0d02e8fc6f97ebe
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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