Dimethylamine → N,N-dimethyl-(2-pyridyl)acetamide

HRID 231596Notes

Reaction equation

HRID 231596 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10]CC)=O.[CH3:13][NH:14][CH3:15]>CO>[CH3:13][N:14]([CH3:15])[C:8](=[O:10])[CH2:7][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 75960Ethyl 2-pyridylacetate

Product 1

HCID 10678588N,N-dimethyl-(2-pyridyl)acetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 5.0 g of ethyl 2-pyridylacetate dissolved in 25 ml of MeOH was added 20 ml of dimethyl amine. The mixture was heated at 90° in a steel autoclave for 96 hrs. The solvent/amine mixture was allowed to evaporate until a residual oil was obtained. The residual oill was distilled to afford 4.5 g of the desired N,N-dimethyl-(2-pyridyl)acetamide as a free-flowing yellow oil, bp 105°-110°/0.5 mm.

Workup

  1. customto evaporate until a residual oil
  2. customwas obtained
  3. distillationThe residual oill was distilled

Sources & evidence

ORD record
ord-fbe29130b7af45a0ad8bdbdccc5f2df4
Source dataset
uspto-grants-1989_07
Patent number
US04847301

Reaction notes

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