Barium Sulfate → 2,4-Difluorobenzaldehyde

HRID 231674

Reaction equation

HRID 231674 reaction equation
S([O-])([O-])(=O)=O.[Ba+2].[F:7][C:8]1[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:9]=1[C:10](Cl)=[O:11]>[Pd].C1C2C(CCCC2)CCC1>[F:7][C:8]1[CH:16]=[C:15]([F:17])[CH:14]=[CH:13][C:9]=1[CH:10]=[O:11]

Participants

5

Reactant 2

HCID 24414Barium SulfateHCID 5880812,4-Difluorobenzoyl chloride

Product 1

HCID 737702,4-Difluorobenzaldehyde

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 7044DecalinSolvent

Conditions

Temperature
130 °C

Procedure

30 ml (27 g) of decahydronaphthalene and 0.5 g (2.3×10-4 ml) of a catalyst of 5% palladium on a barium sulfate support were added to the flask containing the 2,4-difluorobenzoylchloride. The reaction was purged with H2 for 0.25 hour, then the temperature was raised to 130° C. Hydrogen was dispersed through the system for 6 hours. The product 2,4-difluorobenzaldehyde was isolated as a colorless liquid. Yield 9.8 g (82%).

Workup

  1. customThe reaction was purged with H2 for 0.25 hour
  2. additionHydrogen was dispersed through the system for 6 hours

Sources & evidence

ORD record
ord-75dc8a895d0348e8b51de7c7dc829a70
Source dataset
uspto-grants-1989_07
Patent number
US04847442

Linked notes

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