4-Cyclopentylmorpholine → Methyl 1-morpholino-2-oxa-3-aza-bicyclo[4.3.0]non-3-ene-4-carboxylate

HRID 231883

Reaction equation

HRID 231883 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Br[CH2:13][C:14](=[N:19][OH:20])[C:15]([O:17][CH3:18])=[O:16]>>[O:1]1[CH2:6][CH2:5][N:4]([C:7]23[CH2:11][CH2:10][CH2:9][CH:8]2[CH2:13][C:14]([C:15]([O:17][CH3:18])=[O:16])=[N:19][O:20]3)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 134280244-CyclopentylmorpholineHCID 71339048Methyl 3-bromo-2-(hydroxyimino)propanoate

Product 1

HCID 22154614Methyl 1-morpholino-2-oxa-3-aza-bicyclo[4.3.0]non-3-ene-4-carboxylateYield 70.8%

Procedure

4.6 g (30 mmol) of morpholinocyclopentane are reacted with 1.75 g (10 mmol) of methyl 3-bromohydroxyiminopropionate by following the method of Example 1(a). 1.9 g of a colorless oil are obtained.

Sources & evidence

ORD record
ord-5673db6b23e44e349843706667d1b53a
Source dataset
uspto-grants-1989_07
Patent number
US04849524

Linked notes

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