Pyridine → 4-(1-Chloro-2,2,2-trifluoroethyl)phenol

Reaction equation

[CH3:24][c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[F:1][C:2]([CH:3]([OH:4])[c:5]1[cH:6][cH:7][c:8]([OH:11])[cH:9][cH:10]1)([F:12])[F:13].[S:20]([Cl:21])([Cl:22])=[O:23].[cH:14]1[cH:15][cH:16][n:17][cH:18][cH:19]1>>[F:1][C:2]([CH:3]([c:5]1[cH:6][cH:7][c:8]([OH:11])[cH:9][cH:10]1)[Cl:22])([F:12])[F:13]

Participants

Reactant 4

HCID 1049Pyridine

HCID 1140Toluene

HCID 24386Thionyl Chloride

HCID 112869774-(2,2,2-Trifluoro-1-hydroxyethyl)phenol

Product 1

HCID 114584944-(1-Chloro-2,2,2-trifluoroethyl)phenol

Sources & evidence

ORD record: ord-38f24bf4836b4271be723040a4cee4e9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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