4-chloro-N-{4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}-5-(trifluoromethyl)pyrimidin-2-amine → 4-(trans-4-hydroxycyclohexyl)-2-methyl-7-{[2-({4-[(2-oxido-1,3,2-dioxaphosphinan-2-yl)methyl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-4-yl]amino}-2,3-dihydro-1H-isoindol-1-one

Reaction equation

[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([CH2:19][P:20]3(=[O:26])[O:21][CH2:22][CH2:23][CH2:24][O:25]3)[cH:17][cH:18]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[NH2:27][c:28]1[cH:29][cH:30][c:31]([CH:39]2[CH2:40][CH2:41][CH:42]([OH:45])[CH2:43][CH2:44]2)[c:32]2[c:36]1[C:35](=[O:37])[N:34]([CH3:38])[CH2:33]2>>[c:2]1([NH:27][c:28]2[cH:29][cH:30][c:31]([CH:39]3[CH2:40][CH2:41][CH:42]([OH:45])[CH2:43][CH2:44]3)[c:32]3[c:36]2[C:35](=[O:37])[N:34]([CH3:38])[CH2:33]3)[n:3][c:4]([NH:12][c:13]2[cH:14][cH:15][c:16]([CH2:19][P:20]3(=[O:26])[O:21][CH2:22][CH2:23][CH2:24][O:25]3)[cH:17][cH:18]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]