5-Bromo-2-chloropyrimidine → 2-Chloro-5-(2-furyl)pyrimidine

Reaction equation

[Cl:1][C:2]1[N:7]=[CH:6][C:5](Br)=[CH:4][N:3]=1.[O:9]1[CH:13]=[CH:12][CH:11]=[C:10]1[Sn](CCCC)(CCCC)CCCC>>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:10]2[O:9][CH:13]=[CH:12][CH:11]=2)=[CH:4][N:3]=1

Participants

Reactant 2

HCID 6066655-Bromo-2-chloropyrimidine

HCID 43936882-(Tributylstannyl)furan

Product 1

HCID 123565832-Chloro-5-(2-furyl)pyrimidine

Procedure

2-Chloro-5-bromopyrimidine and 2-furyltributyltin are treated in the same manner as in Example 190 to give 2-chloro-5-(2-furyl)pyrimidine.

Sources & evidence

ORD record: ord-1f983a1da36340b0869e30cda784fc40
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728706

Reaction notes

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