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3-Amino-4-methoxycyclobut-3-ene-1,2-dione → 3-Amino-4-[4-(4-piperidinomethylpyrazol-1-yloxy)-butylamino]-cyclobutene-1,2-dione

HRID 232024
Notes
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Reaction equation

HRID 232024 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[N:10][N:11]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:19][C:20]1[C:21](=[O:27])[C:22](=[O:26])[C:23]=1OC>CO>[NH2:19][C:20]1[C:21](=[O:27])[C:22](=[O:26])[C:23]=1[NH:18][CH2:17][CH2:16][CH2:15][CH2:14][O:13][N:11]1[CH:12]=[C:8]([CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:9]=[N:10]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 134522053-Amino-4-methoxycyclobut-3-ene-1,2-dioneHCID 200307904-(4-Piperidinomethylpyrazol-1-yloxy)butylamine

Product 1

HCID 138232173-Amino-4-[4-(4-piperidinomethylpyrazol-1-yloxy)-butylamino]-cyclobutene-1,2-dione

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

2.5 g of 4-(4-piperidinomethylpyrazol-1-yloxy)butylamine and 1.2 g of 3-amino-4-methoxycyclobutene-1,2-dione are introduced into 80 ml of methanol, and the mixture is stirred for 12 hours at 20° C. The solid formed is then filtered off under suction.

Workup

  1. customThe solid formed
  2. filtrationis then filtered off under suction

Sources & evidence

ORD record
ord-4e6670852429443a95807524b615052e
Source dataset
uspto-grants-1989_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04851410

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes