Methanol → 1-Piperazin-1-ylpiperidin-2-one

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][N:11]([N:14]2[C:15](=[O:20])[CH2:16][CH2:17][CH2:18][CH2:19]2)[CH2:12][CH2:13]1.[CH3:21][OH:22].[OH-:23].[OH-:25].[Pd+2:24]>>[NH:8]1[CH2:9][CH2:10][N:11]([N:14]2[C:15](=[O:20])[CH2:16][CH2:17][CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 672331801-(4-Benzylpiperazin-1-yl)piperidin-2-one

Product 1

HCID 672335041-Piperazin-1-ylpiperidin-2-one

Sources & evidence

ORD record: ord-e613ce48a3cd43d28a94abcecc87f0c3
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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