HCID 20031323, compound → HCID 20031395, compound

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:11]2[CH2:16][CH2:15][CH:14]([CH2:17][OH:18])[CH2:13][CH2:12]2)=O)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:11]2[CH2:16][CH2:15][CH:14]([CH2:17][OH:18])[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 20031323HCID 20031323, compound

HCID 21226445Aluminium lithium hydride

Product 1

HCID 20031395HCID 20031395, compound

Procedure

In a manner similar to Preparation 5, react 1-[2-(4-chlorophenyl)acetyl]-4-(hydroxymethyl)piperidine with lithium aluminum hydride to obtain the title compound.

Workup

customIn a manner similar to Preparation 5

Sources & evidence

ORD record: ord-943f1f2d8a2949dfb20204ecdf4bdba0
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04851526

Reaction notes

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