1,2,4-Triazine-3,5(2H,4H)-dione → 2-acetyl-6-bromo-2H-[1,2,4]triazine-3,5-dione
Reaction equation
[Br:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][N:7]=1.O=C1N[C:15](=[O:17])[CH:14]=NN1>C(OC(=O)C)(=O)C>[C:15]([N:6]1[C:5](=[O:8])[NH:4][C:3](=[O:9])[C:2]([Br:1])=[N:7]1)(=[O:17])[CH3:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The 6-bromo-3,5-dioxo-(2H,4H)-1,2,4-triazine (5 g) obtained from the 3,5-dioxo-(2H,4H)-1,2,4-triazine in accordance with the technique described in example 1b is treated with acetic anhydride (50 ml) for 7 hours under reflux. After concentration to dryness under vacuum and taking up in ethyl ether, the precipitate is filtered, centrifuged, and dried under vacuum at 50° C. to give compound 15a (4.6 g).
Workup
- temperatureunder reflux
- concentrationAfter concentration to dryness under vacuum
- filtrationthe precipitate is filtered
- customdried under vacuum at 50° C.
Sources & evidence
- ORD record
- ord-89767eb67e8e42c2876680b03a528ed9
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05591743
Reaction notes
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