2-Chloro-4-fluorotoluene → HCID 19705078, compound

HRID 232630Notes

Reaction equation

HRID 232630 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11](Cl)[C:10]=2[Cl:16])=[C:4]([CH3:17])[N:3]=1.ClC1C=C([F:25])C=CC=1CC#N.ClC1C=C(F)C=CC=1C>>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([F:25])=[CH:11][C:10]=2[Cl:16])=[C:4]([CH3:17])[N:3]=1

Participants

4

Reactant 3

HCID 967472-Chloro-4-fluorotolueneHCID 27250632-Chloro-4-fluorophenylacetonitrileHCID 116734192,4-Diamino-5-(2,3-dichlorophenyl)-6-methylpyrimidine

Product 1

HCID 19705078HCID 19705078, compound

Procedure

This compound was prepared in an analogous manner to the compound of Example 15 from 2-chloro-4-fluorophenylacetonitrile, which was itself prepared from 2-chloro-4-fluorotoluene (Aldrich, mp. 238° C.

Sources & evidence

ORD record
ord-eaed313cd446497ebafdadec033b30e1
Source dataset
uspto-grants-1997_01
Patent number
US05591746

Reaction notes

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