Reaction equation
[C:1]([CH2:4][CH2:5][S:6][CH:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[CH2:11][O:10][C:9]2[CH:18]=[CH:19][C:20]([O:22][CH2:23][C:24]3[CH:33]=[CH:32][C:31]4[C:26](=[CH:27][C:28]([Cl:34])=[CH:29][CH:30]=4)[N:25]=3)=[CH:21][C:8]1=2)(O)=[O:2].[CH3:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[S:42]([NH2:45])(=[O:44])=[O:43]>>[Cl:34][C:28]1[CH:27]=[C:26]2[C:31]([CH:32]=[CH:33][C:24]([CH2:23][O:22][C:20]3[CH:19]=[CH:18][C:9]4[O:10][CH2:11][C:12]5[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=5[CH:7]([S:6][CH2:5][CH2:4][C:1]([NH:45][S:42]([C:37]5[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=5[CH3:35])(=[O:44])=[O:43])=[O:2])[C:8]=4[CH:21]=3)=[N:25]2)=[CH:30][CH:29]=1Participants
3
Procedure
11-(2-Carboxyethylthio)-2-(7-chloroquinolin-2-yl)methoxy-6,11-dihydrodibenz[b,e]oxepine and 2-methylbenzenesulfonamide were used and reacted in the same manner as in Example 39 to obtain the title compound.
Workup
- customreacted in the same manner as in Example 39
Sources & evidence
- ORD record
- ord-6126a5a692fe431ca0b8cf88f6d37eff
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05591752
Linked notes
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