Benzimidazole → Lithium benzimidazolate
Reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH:2]=1.[Li:10]CCCC>C1(C)C=CC=CC=1>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N-:3][CH:2]=1.[Li+:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A slurry of benzimidazole (8.50 g, 36.3 mmol) in toluene (40 mL) at 0° C. was treated with 25.8 mL of a 2.8 M n-BuLi (72.2 mmol) solution in hexanes. This solution mixture was then refluxed for one day during which time the slurry became off-white. The slurry was then filtered over a medium glass frit and dried to give a white solid.
Workup
- temperatureThis solution mixture was then refluxed for one day during which time the slurry
- filtrationThe slurry was then filtered over a medium glass frit
- customdried
- customto give a white solid
Sources & evidence
- ORD record
- ord-a3fec071d6a44a0a9e0f5f1bd556fe97
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06852446B2
Reaction notes
Loading…