Dimethyl Sulfoxide → 7'-Bromo-3'-methoxyspiro[2,6-dihydro-1,4-oxazine-5,5'-chromeno[2,3-c]pyridine]-3-amine

Reaction equation

[Br:1][c:2]1[cH:3][c:4]2[c:14]([cH:15][cH:16]1)[O:13][c:7]1[c:6]([cH:11][c:10]([Cl:12])[n:9][cH:8]1)[C:5]21[CH2:17][O:18][CH2:19][C:20]([NH2:22])=[N:21]1.[CH3:23][O-:24].[CH3:26][S:27]([CH3:28])=[O:29].[Na+:25]>>[Br:1][c:2]1[cH:3][c:4]2[c:14]([cH:15][cH:16]1)[O:13][c:7]1[c:6]([cH:11][c:10]([O:24][CH3:23])[n:9][cH:8]1)[C:5]21[CH2:17][O:18][CH2:19][C:20]([NH2:22])=[N:21]1

Participants

Reactant 4

HCID 679Dimethyl Sulfoxide

HCID 923Sodium Ion

HCID 3826051Methoxide

HCID 584659017-Bromo-3-chloro-2',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 674392897'-Bromo-3'-methoxyspiro[2,6-dihydro-1,4-oxazine-5,5'-chromeno[2,3-c]pyridine]-3-amine

Sources & evidence

ORD record: ord-681b1db9f583482aa3799f7bde9c0770
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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