O-methylhydroxylammonium chloride → 2-Bromophenylglyoxylic Acid Methyl Ester-O-methyloxime
Reaction equation
[CH3:1][O:2][NH3+:3].[Cl-].[Br:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12](=O)[C:13]([O:15][CH3:16])=[O:14]>CO>[CH3:1][O:2][N:3]=[C:12]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[Br:5])[C:13]([O:15][CH3:16])=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5.2 g (62 mmol) of 0-methylhydroxylamine hydrochloride is added to a solution of 10 g (41 mmol) of methyl 2-bromophenylglyoxylate in 30 ml of methanol, and the mixture is refluxed for 2 hours. The mixture is evaporated down, and the residue is taken up in ethyl acetate and washed with water. After drying and evaporating down, there remains 6.9 g (62%) of compound E.
Workup
- temperaturethe mixture is refluxed for 2 hours
- customThe mixture is evaporated down
- washwashed with water
- customAfter drying
- customevaporating down
Sources & evidence
- ORD record
- ord-d1c21c15754549efba5b4bfe8c4a63c4
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05594020
Reaction notes
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