N-methyl-N-(trimethylsilyl)trifluoroacetamide → HCID 178504300, compound
Reaction equation
[NH:1]1[CH:8]=[CH:7][C:5]([NH2:6])=[N:4][C:2]1=[O:3].CN([Si:17]([CH3:20])([CH3:19])[CH3:18])C(=O)C(F)(F)F>ClCCl>[CH3:18][Si:17]([N:6]([Si:17]([CH3:20])([CH3:19])[CH3:18])[C:5]1[CH:7]=[CH:8][NH:1][C:2](=[O:3])[N:4]=1)([CH3:20])[CH3:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A bis-trimethylsilylcytosine solution was prepared by suspending 5.78 g of cytosine in 20 ml of dichloromethane and adding 20.57 ml of N-methyl-N-trimethylsilyltrifluoroacetamide in 10 ml of dichloromethane and cooling the resulting solution to 0° C.
Sources & evidence
- ORD record
- ord-da6a82f444c049bb8e5c3be1ee440914
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05594124
Reaction notes
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